An oncolytic adenovirus

Details An oncolytic adenovirus An oncolytic adenovirus

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 35/76 (2006.01) A61K 48/00 (2006.01) C12N 15/861 (2006.01)

Patent

CA 2380537

Viral vectors and methods of making such vectors are described that preferentially kill neoplastic but not normal cells, the preferred vector being an adenovirus that has the endogenous promoters in the E1A and/or E4 regions substituted with a tumor specific promoter which is preferably E2F responsive.

L'invention concerne des vecteurs viraux et leurs procédés de fabrication. Lesdits vecteurs viraux tuent, de préférence, les cellules néoplasique mais pas les cellules normales, le vecteur préféré étant un adénovirus dont les promoteurs endogènes se trouvant dans les régions E1A and/or E4 sont substitués par un promoteur spécifique de tumeur qui est de préférence sensible à E2F.

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