An oral formulation for ileum administering comprising an...

A - Human Necessities – 61 – K

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A61K 31/554 (2006.01) A61K 9/22 (2006.01) A61K 9/52 (2006.01) A61K 31/00 (2006.01) A61K 45/00 (2006.01) A61K 47/00 (2006.01) A61P 1/12 (2006.01) A61P 3/06 (2006.01)

Patent

CA 2379105

An oral pharmaceutical formulation comprising an inhibitor compound of the ileal bile acid transport (IBAT inhibitor compound) and a therapeutically acceptable carrier characterised in that the formulation is designed to deliver the IBAT inhibitor compound in the ileum. The IBAT inhibitor compound can also be administered in combination with a bile acid binder to alleviate possible side effects of therapy with IBAT inhibitor compound, such as for instance diarrhoea. The bile acid binder may be formulated for colon release.

Cette formulation pharmaceutique orale, qui comprend un composé inhibiteur du transport d'acides biliaires présents dans l'iléon (composé inhibiteur de l'IBAT) et un excipient admissible du point du vue thérapeutique, se caractérise par le fait qu'elle est conçue pour libérer ce composé inhibiteur de l'IBAT dans l'iléon. Ce composé inhibiteur de l'IBAT peut également être administré associé à un agent de liaison aux acides biliaires afin d'atténuer d'éventuels effets secondaires d'une thérapie faisant intervenir des composé inhibiteurs de l'IBAT, la diarrhée notamment. Cet agent de liaison des acides biliaires peut être formulé pour être libéré dans le côlon.

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