An otorhinological delivery device

A - Human Necessities – 61 – L

Patent

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Details

A61L 31/06 (2006.01) A61K 9/00 (2006.01) A61L 31/16 (2006.01) A61M 31/00 (2006.01) A61P 11/02 (2006.01) A61P 11/04 (2006.01) A61P 27/16 (2006.01) A61K 31/573 (2006.01)

Patent

CA 2513544

The invention relates to an otorhinological delivery device comprising at least one pharmaceutically active agent. According to the invention the device comprises a core comprising said at least one pharmaceutically active agent wherein said core is made of an elastomer composition selected from the group consisting of poly(dimethylsiloxane), a siloxane-based elastomer comprising 3,3,3-trifluoropropyl groups attached to the Si~atoms of the siloxane units, a siloxane-based elastomer comprising poly(alkylene oxide) groups and mixtures thereof, and a membrane encasing said core, said membrane being made of a same or a different elastomer composition than said core, said elastomer composition being selected from the group consisting of poly(dimethylsiloxane), a siloxane-based elastomer comprising 3,3,3- trifluoropropyl groups attached to the Si~atoms of the siloxane units, a siloxane-based elastomer comprising poly(alkylene oxide) groups and mixtures thereof. The invention is characterized in that the pharmaceutically active agent is selected from the group comprising anti-allergic agents, anti- inflammatory agents, anti-fungicides, glucocorticoids and mixtures thereof.

L'invention concerne un dispositif de distribution oto-rhinologique comprenant au moins un agent actif d'un point de vue pharmaceutique. Le dispositif de l'invention comprend une partie centrale contenant au moins un agent actif d'un point de vue pharmaceutique. Ladite partie centrale est faite d'une composition élastomérique sélectionnée dans le groupe composé de poly(diméthylsiloxane), d'un élastomère à base de siloxane comprenant des groupes de 3,3,3-trifluoropropyle rattachés aux atomes Si des unités de siloxane, d'un élastomère à base de siloxane comprenant des groupes de poly(alkylène oxyde), et de mélanges de ceux-ci, et une membrane renfermant ladite partie centrale. Ladite membrane est faite d'une composition élastomérique identique ou différente de celle de ladite partie centrale, ladite composition élastomérique étant sélectionnée dans le groupe composé de poly(diméthylsiloxane), d'un élastomère à base de siloxane comprenant des groupes de 3,3,3-trifluoropropyle rattachés aux atomes Si des unités de siloxane, d'un élastomère à base de siloxane comprenant des groupes de poly(alkylène oxyde), et de mélanges de ceux-ci. L'invention se caractérise en ce que l'agent actif d'un point de vue pharmaceutique est sélectionné dans le groupe comprenant les agents anti-allergiques, les agents anti-inflammatoires, les anti-fongicides, les glucocorticoïdes et des mélanges de ceux-ci.

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