An oxime derivative for use as a glucokinase activator

Details An oxime derivative for use as a glucokinase activator An oxime derivative for use as a glucokinase activator

C - Chemistry, Metallurgy

07

D

C07D 513/04 (2006.01) A61K 31/426 (2006.01) A61K 31/437 (2006.01) A61K 31/495 (2006.01) C07D 241/20 (2006.01) C07D 277/46 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2613303

The problem of the present invention is to provide a useful compound as a glucokinase activating agent, which is the oxime derivative of the formula [I]: wherein Ring A is aryl or heteroaryl; Q is cycloalkyl, heterocycle, alkyl or alkenyl; Ring T is heteroaryl or heterocycle; R1 and R2 are independently hydrogen atom, halogen atom, cycloalkylsulfonyl or the like; R3 and R4 are independently hydrogen atom, hydroxy, oxo, halogen atom or the like; R5 is hydrogen atom, halogen atom, cyano, nitro, tetrazolyl or the like; or a pharmaceutically acceptable salt thereof.

L'invention concerne un composé utilisé comme agent d'activation de la glucokinase, qui est un dérivé d'oxime représenté par la formule [I]. Dans cette formule, le noyau A représente aryle ou hétéroaryle; Q représente cycloalkyle, hétérocycle, alkyle ou alcényle; le noyau T représente hétéroaryle ou hétérocycle; R1 et R2 représentent indépendamment un atome d'hydrogène, un atome d'halogène, cycloalkylsulfonyle ou analogue; R3 et R4 représentent indépendamment un atome d'hydrogène, hydroxy, oxo, un atome d'halogène ou analogue; R5 représente un atome d'hydrogène, un atome d'halogène, cyano, nitro, tétrazolyle ou analogue. L'invention concerne également un sel de ce composé pharmaceutiquement acceptable.

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