C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01) A61K 31/444 (2006.01) A61P 25/00 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01)
Patent
CA 2637545
Disclosed are novel anabaseine derivatives that act as agonists of the .alpha.7 nAChR. Also disclosed are pharmaceutical compositions, methods- of treating inflammatory conditions, methods of treating CNS disorders, methods for inhibiting cytokine release from mammalian cells and methods for the preparation of the novel compounds.
La présente invention concerne de nouveaux dérivés d'anabaséine qui agissent comme agonistes du récepteur .alpha.7 nAChR. L'invention concerne également des compositions pharmaceutiques, des procédés de traitement de troubles inflammatoires, des procédés de traitement de troubles du SNC, des procédés d'inhibition de la libération des cytokines à partir de cellules de mammifères et des procédés de préparation des nouveaux composés.
Elbaum Daniel
Habgood Gregory J.
Critical Therapeutics Inc.
Elbaum Daniel
Gowling Lafleur Henderson Llp
Habgood Gregory J.
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