A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/445 (2006.01) A61K 9/08 (2006.01) A61K 47/02 (2006.01) A61K 47/26 (2006.01) A61P 23/00 (2006.01)
Patent
CA 2308495
A pharmaceutically acceptable aqueous solution which is isobaric or hyperbaric, and isotonic, with respect to cerebrospinal fluid (CSF), comprises a 1-alkyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide anaesthetic agent such as bupivacaine or levobupivacaine and a saccharide. If the amount of the anaesthetic agent is no more than 0.75 % w/v, a salt or another additional non-saccharide is present. Accordingly, the amount of the saccharide can be kept below that which would provide isotonicity in the absence of the additional non-saccharide.
L'invention concerne une solution aqueuse pharmaceutiquement acceptable, qui est isobare ou hyperbare, et isotonique, par rapport au liquide céphalo-rachidien. Ladite solution comprend un agent anesthésique 1-alkyl-N-(2,6-diméthylphényl)-2-pipéridinecarboxamide tel que bupivacaïne ou lévobupivacaïne, et un saccharide. Si la dose d'agent anesthésique ne dépasse pas 0,75 % m/v, un sel ou un autre additif non saccharide est présent. En conséquence, la dose de saccharide peut être maintenue au-dessous de celle qui entraînerait une isotonicité en l'absence d'un additif non-saccharide.
Darwin Discovery Limited
Torys Llp
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