Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds

Details Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds

C - Chemistry, Metallurgy

07

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167/208, 260/207

C07D 209/34 (2006.01) C07D 209/42 (2006.01) C07D 401/06 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01)

Patent

CA 1256104

ANALGESIC AND ANTIINFLAMMATORY 1,3-DIACYL-2-OXINDOLE COMPOUNDS Abstract Certain novel 2-oxindole compounds, having an acyl substituent at both the 1-position and the 3-position, are inhibitors of the cyclooxygenase (CO) and lipoxygenase (LO) enzymes, and are useful as analgesic agents and antiinflammatory agents in mammalian subjects. These 1,3-diacyl-2-oxindole compounds are of particular value for acute administration for ameliorating pain in human patients recovering from surgery or trauma, and also for chronic administration to human subjects for alleviating the symptoms of chronic diseases such as rheumatoid arthritis and osteoarthritis.

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