Analgesic carboxylic acid amide derivatives

Details Analgesic carboxylic acid amide derivatives Analgesic carboxylic acid amide derivatives

C - Chemistry, Metallurgy

07

D

167/211, 260/278

C07D 401/06 (2006.01) A61K 31/445 (2006.01) C07D 211/26 (2006.01) C07D 241/04 (2006.01) C07D 265/30 (2006.01) C07D 279/12 (2006.01) C07D 409/06 (2006.01) C07D 413/06 (2006.01) C07D 417/06 (2006.01)

Patent

CA 1340541

Analgesic compounds are of the general formula (I): <SEE FIG.1> in which, R 1 and R 2 each represents hydrogen or C1-C6 alkyl, or R 1 and R 2 together with the nitrogen atom to which they are attached form a heterocycle: E represents methylene, sulphur, oxygen or imino group optionally substituted with C1-C6 alkyl or aralkyl; ring A is aryl or heteroacyl ring, optionally substituted; R 3 is hydrogen or C1-C6 alkyl and R 4 is hydrogen or R 3 and R 4 together represent a group of formula (IV): -(CR a R a)m-C(=Y)- (IV) (wherein R a and R a is C1-C6 alkyl or hydrogen, up to a maximum of 3 alkyl groups, m is 1, 2, or 3, and Y is two hydrogens or oxygen); provided that when E represents a methylene group, then R 3 is a C1-C6 alkyl group or R 3 and R 4 together represent a group of the formula (IV).

609076

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