Analgesic composition and method

Details Analgesic composition and method Analgesic composition and method

A - Human Necessities

61

K

A61K 31/517 (2006.01) A61K 31/485 (2006.01) A61K 31/519 (2006.01) A61P 25/04 (2006.01)

Patent

CA 2485337

A pharmaceutical analgesic composition comprising an opioid analgesic agent and a compound that binds to the SS1 or SS2 subunit of a sodium channel, such as tetrodotoxin and saxitoxin, and analogs thereof. Administration of an opioid analgesic agent and a compound that binds to the SS1 or SS2 subunit of a sodium channel, such as tetrodotoxin and saxitoxin, and analogs thereof, produces analgesia in the treatment of pain in mammals.

Cette invention se rapporte à une composition pharmaceutique analgésique qui comprend un agent analgésique à base d'opioïdes et un composé qui se fixe à la sous-unité SS1 ou SS2 d'un canal de sodium, telle que la tétrodotoxine et la saxitoxine, ainsi qu'à des analogues de cette composition. L'administration d'un tel agent analgésique à base d'opioïdes et d'un tel composé qui se fixe à la sous-unité SS1 ou SS2 d'un canal de sodium, telle que la tétrodotoxine et la saxitoxine, et d'analogues de ceux-ci produit l'effet analgésique recherché lors du traitement de la douleur chez les mammifères.

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