Analgesic composition of topically applied nonsteroidal...

A - Human Necessities – 61 – K

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Details

A61K 31/135 (2006.01) A61K 9/06 (2006.01) A61K 31/167 (2006.01) A61K 31/192 (2006.01) A61K 31/196 (2006.01) A61K 31/365 (2006.01) A61K 31/485 (2006.01) A61K 31/616 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2679892

The present invention relates to pharmaceutical formulations comprising at least two compounds, one effecting opioid analgesia and one effecting cyclooxygenase 1 and 2 activity, in amounts sufficient to potentiate an antinociceptive response when both compounds are topically administered in a physiologically acceptable topical excipient. The pharmaceutical formulations of the present invention are used to prevent or relieve acute pain and chronic peripheral neuropathy and/or neuropathic inflammation in a patient in need of such treatment.

La présente invention porte sur des formulations pharmaceutiques comprenant au moins deux composés, l'un destiné à produire une analgésie opioïde et l'autre destiné à produire une activité cyclooxygénase 1 et 2, en quantités suffisantes pour potentialiser une réponse antinociceptive lorsque les deux composés sont administrés topiquement dans un excipient topique physiologiquement acceptable. Les formulations pharmaceutiques de la présente invention sont utilisées pour prévenir ou soulager la douleur aiguë et les neuropathies périphériques chroniques et/ou l'inflammation neuropathique chez un patient ayant besoin d'un tel traitement.

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