A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/195 (2006.01) A61K 31/415 (2006.01) A61K 31/47 (2006.01)
Patent
CA 2296336
The present invention is directed to novel combinations of anti-epileptic compounds that demonstrate pain alleviating properties, with compounds selected from the group consisting of analgesics, NMDA receptor antagonists, and NSAIDs and pharmaceutical compositions comprising same. It has been discovered that the administration of anti- epileptic compounds that demonstrate pain alleviating properties in these novel combinations results in an improved reduction in the frequency and severity of pain. It is also believed that the incidence of unwanted side effects can be reduced by these novel combinations in comparison to using higher doses of a single agent treatment to achieve a similar therapeutic effect. The present invention is also directed to methods of using effective amounts of the novel pharmaceutical compositions to treat pain in mammals.
L'invention concerne des associations de composés anticonvulsivants, possédant une activité antalgique, avec des composés choisis dans le groupe comprenant les analgésiques, les antagonistes du récepteur du NMDA et les AINS, ainsi que des compositions pharmaceutiques renfermant lesdites associations. Il a été découvert que l'administration de composés anticonvulsivants possédant une activité antalgique dans ces nouvelles associations accentue la diminution de la fréquence et de l'intensité des douleurs. On suppose en outre que ces nouvelles associations peuvent diminuer l'incidence d'effets secondaires indésirables par rapport à l'utilisation de doses plus élevées d'un seul produit pour obtenir un effet comparable. L'invention concerne également des méthodes qui permettent d'utiliser des quantités efficaces de ces nouvelles compositions pharmaceutiques pour traiter la douleur chez les mammifères.
Magnus-Miller Leslie
Saltel Douglas A.
Macrae & Co.
Warner-Lambert Company
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