A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/485 (2006.01) A61K 9/00 (2006.01) A61P 25/04 (2006.01)
Patent
CA 2392013
An analgesic composition in parenteral unit dosage form or in a unit dosage form suitable for delivery via the mucosa comprising an amount of buprenorphine which is less than the clinical dose required to achieve pain relief and an amount of naloxone such that the ratio by weight of buprenorphine to naloxone is in the range of from 12.5:1 to 27.5:1, or an amount of naltrexone or nalmefene such that the ratio by weight of buprenorphine to naltrexone or nalmefene is in the range of from 12.5:1 to 22.5:1, whereby the analgesic action of the buprenorphine is potentiated by the low dose of naloxone, naltrexone or nalmefene.
L'invention concerne une composition analgésique sous forme de dosage unitaire parentéral ou sous forme de dosage unitaire adapté à une administration par la muqueuse, comportant une quantité de buprénorphine inférieure à la dose clinique nécessaire à supprimer la douleur, et une quantité de naloxone de manière que le rapport massique entre la buprénorphine et la naloxone se situe entre 12,5:1 et 27,5:1, ou une quantité de naltrexone ou de nalméfène de manière que le rapport massique entre la buprénorphine et la naltrexone ou le nalméfène se situe entre 12,5:1 et 22,5:1, l'activité analgésique de la buprénorphine étant potentialisée par la faible dose de naloxone, de naltrexone, ou de nalméfène.
Chapleo Christopher Bourne
Mccormack Keith
Varey Nicolas Calvert
Fetherstonhaugh & Co.
Reckitt Benckiser Healthcare (uk) Limited
LandOfFree
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