A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/16 (2006.01) A61P 17/04 (2006.01) A61P 29/00 (2006.01)
Patent
CA 2725628
The invention relates to the use of the peptide toxin APETx2 that blocks the ASIC3 cationic channels and that is derived from the Anthopleura elegantissima sea anemone, and to the use of the analogs and derivatives thereof as a drug, particularly as an analgesic against pain associated with the activation of ASIC3 (Acid Sensing Ion Channel 3) channels, in particular pain occurring upon an inflammation and potentially upon any painful situation associated with tissue acidosis (ischemiae, fractures, hematoma, oedema, phlyctena, local infections, tissue lesions, ocular wounds, tumours, etc.)
La présente invention est relative à l'utilisation de la toxine peptidique APETx2 qui bloque les canaux cationiques de type ASIC3 et qui est issue de l'anémone de mer Anthopleura elegantissima, ainsi que de ses analogues et de ses dérivés, comme médicament, notamment en tant qu'analgésique, vis-à-vis de la douleur qui est associée à l'activation des canaux de type ASIC3 (Acid Sensing Ion Channel 3), particulièrement celle qui surgit lors d'une inflammation, et aussi potentiellement lors de toutes situations douloureuses associées à une acidose tissulaire (ischémies, fractures, hématomes, oedèmes, phlyctènes, infections locales, lésions tissulaires, blessures oculaires, tumeurs, etc.).
Deval Emmanuel
Diochot Sylvie
Lazdunski Michel
Lingueglia Eric
Noel Jacques
Centre National de La Recherche Scientifique (cnrs)
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Universite Nice Sophia Antipolis
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