Analgesic method with dynorphin analogues truncated at the...

Details Analgesic method with dynorphin analogues truncated at the... Analgesic method with dynorphin analogues truncated at the...

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/33 (2006.01) C07K 7/08 (2006.01) C07K 14/665 (2006.01)

Patent

CA 2198348

Dynorphin A analogues truncated at the N-terminus are used as analgesics to relieve pain, such as painful neuropathies where the analgesic effect is not opioid. Novel, analgesic peptides that are des-(Tyr-Gly-Gly) with respect to endogenous dynorphin are also disclosed.

Des analogues de dynorphine A tronqués au niveau de la terminaison N sont utilisés comme analgésiques pour soulager la douleur, telle que des neuropathies douloureuses où l'effet analgésique n'est pas opioïde. De nouveaux peptides analgésiques qui sont des-(Tyr-Gly-Gly) par rapport à la dynorphine endogène sont également décrits.

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