Analgesic pentapeptides

Details Analgesic pentapeptides Analgesic pentapeptides

C - Chemistry, Metallurgy

07

K

530/7.06

C07K 14/70 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1138440

ANALGESIC PENTAPEPTIDES Abstract of the Disclosure Pentapeptides of the formula: Image wherein R1 is hydrogen, methyl, ethyl, propyl, 2- methyl-2-pentenyl, 2-methyl-1-pentenyl, cyclopropyl- methyl, or cyclobutylmethyl; R2, R3, and R4 are, independently, hydrogen or methyl; and X is -OH, -NH2, -NHCnH2n+1 where n is 1, 2, 3, and 4, -OR5, or CH2OR5, where R5 is hydrogen or lower alkyl of from 1 to 4 carbon atoms; or a pharmaceutically acceptable salt thereof; have analgesic activity upon administration to warm-blooded animals.

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