Analgesic substituted piperidylidene-2-sulfon (cyan) amide...

C - Chemistry – Metallurgy – 07 – D

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C07D 211/72 (2006.01) A61K 31/445 (2006.01) C07D 211/74 (2006.01) C07D 401/12 (2006.01)

Patent

CA 1255680

TITLE ANALGESIC SUBSTITUTED PIPERIDYLIDENE-2-SULFON(CYAN)AMIDE DERIVATIVES INVENTORS Edward F. Knaus Brent K. Warren Theodore A. Ondrus ABSTRACT OF THE DISCLOSURE Pharmaceutical compounds of the general formula (1) have been prepared Image (1) and non-toxic pharmaceutically acceptable salts thereof, wherein R1 is a lower alkyl, phenyl lower alkyl, amino substituted phenyl lower alkyl, nitro substituted phenyl lower alkyl, cycloalkyl lower alkyl or a lower alkenyl substituent, R2 is a member selected from the group consisting of a cyano, pyridylsulfonyl, lower alkyl substituted sulfonyl, phenylsul- fonyl, lower alkyl substituted phenylsulfonyl, lower alkoxy substituted phenylsulfonyl, halogen substituted phenylsulfonyl, nitro substituted phenylsulfonyl, amino substituted phenylsulfonyl and lower alkyl amido substituted phenylsulfonyl; R3 is a hydrogen or halogen atom; and R4 is a hydrogen, lower alkyl or lower alkoxy substituent, lower denoting a straight or branched chain having from 1-4 carbon atoms. These compounds exhibit analgesic agonist activity or analgesic agonist-antagonist activities.

431773

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