Analgesic uses of norketamine and ketamine/norketamine prodrugs

C - Chemistry – Metallurgy – 07 – C

Patent

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Details

C07C 271/56 (2006.01) A61K 31/165 (2006.01) A61K 31/166 (2006.01) A61K 31/216 (2006.01) A61K 31/27 (2006.01) A61K 31/357 (2006.01) A61K 31/365 (2006.01) A61K 31/4015 (2006.01) A61K 31/4035 (2006.01) A61P 29/00 (2006.01) C07C 229/46 (2006.01) C07C 271/24 (2006.01) C07C 323/62 (2006.01) C07D 207/408 (2006.01) C07D 209/48 (2006.01) C07D 307/88 (2006.01) C07D 317/34 (2006.01)

Patent

CA 2506615

The present invention relates to norketamine and ketamine/norketamine prodrugs, and methods of their use and analgesics. More particulary, the invention relates to norketamine and N-conjugated prodrugs of ketamine and norketamine, and methods of using these agents for the management of chronic pain without requiring administration of narcotics. The invemtion relates to self-management of pain on an outpatient basis comprising administering via conventional routes, including transdermal, nasal, rectal, oral, transmucosal, intravenous, intramuscular, and other routes, one or more doses of norketamine and/or ketamine/norketamine prodrugs effective to alleviate pain to a subject suffering from pain.

La présente invention concerne de la norkétamine et des promédicaments de kétamine/norkétamine, ainsi que des méthodes d'utilisation de ces derniers en tant qu'analgésiques. Plus particulièrement, l'invention concerne de la norkétamine et des promédicaments N-conjugués de kétamine et de norkétamine, ainsi que des méthodes d'utilisation desdits agents pour la gestion de la douleur chronique sans nécessiter l'administration de narcotiques. L'invention concerne l'autogestion de la douleur sur une base de consultation externe consistant à administrer par des voies classiques, notamment transdermiques, nasales, rectales, orales, transmucosales, intraveineuses, intramusculaires et d'autres voies, une ou plusieurs doses de norkétamine et/ou de promédicaments de kétamine/norkétamine efficaces pour soulager la douleur chez un sujet souffrant de douleur.

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