Analgesics for nasal administration

Details Analgesics for nasal administration Analgesics for nasal administration

A - Human Necessities

61

K

A61K 47/36 (2006.01) A61K 9/00 (2006.01) A61K 9/08 (2006.01) A61K 31/195 (2006.01) A61K 31/196 (2006.01) A61K 31/405 (2006.01) A61K 31/407 (2006.01) A61K 31/485 (2006.01) A61K 31/54 (2006.01) A61K 31/5415 (2006.01) A61K 47/34 (2006.01) A61K 47/38 (2006.01)

Patent

CA 2479718

An analgesic and a delivery agent are combined in a pharmaceutical composition such that, on introduction into the nasal cavity of a patient to be treated, the analgesic may be delivered to the bloodstream to produce within 30 minutes a therapeutic plasma concentration, Cther, of 0.2 ng/ml or greater which is maintained for a duration Tmaint of at least 2 hours. The analgesic may be an opioid analgesic or a non-steroidal anti-inflammatory drug.

L'invention concerne une composition pharmaceutique renfermant un analgésique et un excipient. Lorsque la composition est introduite dans la cavité nasale d'un patient à traiter, l'analgésique pénètre dans le circuit sanguin et produit, dans les 30 minutes qui suivent, une concentration plasmatique thérapeutique, C¿ther?, supérieure ou égale à 0,2 ng/ml, pendant une durée T¿maint? d'au moins 2 heures. L'analgésique peut être un analgésique opioïde ou un anti-inflammatoire non stéroïdien.

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