Analgetic pyrroline derivatives

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 401/04 (2006.01) A61K 31/40 (2006.01) A61K 31/4439 (2006.01) A61K 31/444 (2006.01) A61P 25/04 (2006.01) A61P 29/00 (2006.01) C07D 207/06 (2006.01) C07D 207/20 (2006.01) C07D 207/22 (2006.01) C07D 207/267 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2458015

A method for inducing analgesia and/or inhibiting abuse of abusive substances includes administration of d-methadone metabolites or their structural analogs. The d-methadone metabolites, EMDP and EDDP, and their structural analogs may be incorporated into a suitable pharmaceutical composition for administration to patients. The invention includes the method itself, certain structural analogs, and pharmaceutical compositions for use in accordance with the method.

L'invention concerne une méthode pouvant induire une analgésie et/ou inhiber l'abus de substances nocives, qui consiste à administrer des métabolites de d-méthadone ou leurs analogues structuraux. Les métabolites de d-méthadone (EMDP et EDDP) et leurs analogues structuraux peuvent être incorporés dans une composition pharmaceutique appropriée destinée à être administrée à des patients. L'invention concerne la méthode proprement dite, certains analogues structuraux, et des compositions pharmaceutiques utilisables selon le procédé de l'invention.

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