C - Chemistry – Metallurgy – 08 – B
Patent
C - Chemistry, Metallurgy
08
B
C08B 37/00 (2006.01) A61K 38/18 (2006.01) A61K 39/395 (2006.01) A61K 49/00 (2006.01) A61K 49/14 (2006.01) A61K 51/06 (2006.01) A61K 51/08 (2006.01) C07B 61/00 (2006.01) C07C 237/22 (2006.01) C07C 291/10 (2006.01) C07C 309/18 (2006.01) C07C 309/61 (2006.01) C07D 209/42 (2006.01) C07D 215/48 (2006.01) C07D 231/56 (2006.01) C07D 307/68 (2006.01) C07D 317/58 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 407/12 (2006.01) C07F 9/38 (2006.01) C07K 5/062 (2006.01) G01N 33/543 (2006.01)
Patent
CA 2230385
The present invention provides methods for modulating the interaction between neuregulins and neuregulin-specific glycosaminoglycan sequences. The invention identifies compounds that have the ability to mimic a specific neuregulin- glycosaminoglycan sequence interaction and provides methods for their selection and use as therapeutic agents.
L'invention concerne des procédés de modulation de l'interaction entre des neurégulines et des séquences de glycosaminoglycanes spécifiques des neurégulines. L'invention identifie des composés capables d'imiter une interaction spécifique entre les séquences de neurégulines-glycosaminogycanes et constitue un procédé permettant leur sélection ainsi que leur utilisation en tant qu'agents thérapeutiques.
Jacobson Alan R.
Mahanthappa Nagesh K.
Marchionni Mark A.
Rusche James
Sudhalter Judith
Cambridge Neuroscience Inc.
Repligen Corporation
Smart & Biggar
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