C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/46 (2006.01) A61K 31/4035 (2006.01)
Patent
CA 2331461
The invention provides new and useful analogs of 2-phthalimidinoglutaric acid. These analogs include DL-2-methyl-2- phthalimidinoglutaric acid and hydroxylated analogs of 2-phthalimidinoglutaric wherein each of R3 and R4 are independently H or OH. The invention also provides processes for making these analogs. The invention also provides the two individual enantiomers of DL-2-methyl-2--phthalimidinoglutaric acid. (R)-(+)-2-methyl-2- phthalimidinoglutaric acid and (S)-(-)-2-methyl-2-phthalimidinoglutaric acid, and processes or separating these individual enantiomers from the racemate. Further, the invention provides methods for inhibiting angiogenesis and treating angiogenesis-associated diseases. including cancer and macular degeneration, by administering one or more of these compounds.
La présente invention concerne des analogues nouveaux et utiles de l'acide 2-phthalimidinoglutarique. Les analogues comprennent l'acide DL-2- méthyl-2- phthalimidinoglutarique et des analogues hydroxylés de 2-phthalimidinoglutarique. L'invention englobe également des procédés de fabrication de ces analogues. Elle concerne également les deux enantiomères de l'acide DL-2- méthyl-2- phthalimidinoglutarique, l'acide (R)-(+)-2- méthyl-2- phthalimidinoglutarique et l'acide (S)-(-)-2-méthyl-2-phthalimidinoglutarique ainsi que les procédés permettant de séparer ces énantiomères individuels du racémique vrai. De plus, cette invention, s'intéresse à des méthodes permettant d'inhiber l'angiogenèse et de traiter des affections en rapport avec l'angiogenèse, dont le cancer et la dégénérescence maculaire, par administration d'un ou de plusieurs de ces composés.
D'amato Robert J.
Fogler William E.
Green Shawn J.
Madsen John W.
Papathanassiu Adonia E.
Entremed Inc.
Finlayson & Singlehurst
The Children's Medical Center Corporation
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