Analogs of acidic fibroblast growth factor having enhanced...

Details Analogs of acidic fibroblast growth factor having enhanced... Analogs of acidic fibroblast growth factor having enhanced...

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61K 38/18 (2006.01) C07K 14/50 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2098484

2098484 9211360 PCTABS00014 Novel analogs of aFGF which are provided in accordance with the present invention. These analogs are more stable and exhibit greater biological activity in the absence of heparin than naturally occurring aFGF. Enhanced stability may be achieved by substituting at least one amino acid having a higher loop-forming potential for an amino acid residue having a lower loop-forming potential in the naturally occurring aFGF molecule in the area of amino acids 90 to 97. The novel analogs of the present invention are especially useful in therapeutic applications.

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