Analogs of cc-1065 and the duocarmycins

Details Analogs of cc-1065 and the duocarmycins Analogs of cc-1065 and the duocarmycins

C - Chemistry, Metallurgy

07

D

C07D 209/70 (2006.01) C07D 209/94 (2006.01) C07D 209/96 (2006.01) C07D 403/06 (2006.01) C07D 417/14 (2006.01) C07D 487/04 (2006.01) C07D 487/10 (2006.01)

Patent

CA 2255703

Analogs of antitumor antibiotics CC-1065 and the duocarmycins are synthesized which possess systematic and extensive modifications in the DNA binding subunits attached to a 1,2,9,9a-tetra-hydro-cyclo-propa[c]benz[e]indol-4-one (CBI) alkylation subunit. The analogs have potent cytotoxic activity and are efficacious antitumor compounds.

Cette invention se rapporte à la synthèse d'analogues d'antibiotiques antitumoraux CC-1065 et de duocarmycines qui possèdent des modifications systématiques et étendues au niveau des sous-unités de liaison à l'ADN attachées à une sous-unité d'alkylation 1,2,9,9a-tétra-hydro-cyclo-propa[c]benz[e]indol-4-one (CBI). Ces analogues possèdent une puissante activité cytotoxique et sont des composés antitumoraux efficaces.

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