Analogs of duocarmycin and cc-1065

Details Analogs of duocarmycin and cc-1065 Analogs of duocarmycin and cc-1065

C - Chemistry, Metallurgy

07

D

C07D 223/32 (2006.01) C07D 223/14 (2006.01) C07D 225/04 (2006.01) C07D 487/04 (2006.01) C07D 487/10 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2290789

Analogs and derivatives of duocarmycin and CC-1065 are provided. The compounds have use as antitumor antibiotics and as cell toxicity agents. The compounds have sequences specific DNA alkylating activity.

L'invention concerne des analogues et des dérivés de duocarmycine et de CC-1065. Ces composés s'utilisent comme antibiotiques antitumoraux et comme agents de toxicité cellulaire. Ils possèdent une activité d'alkylation spécifique à certaines séquences d'ADN.

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