Analogs of glycoprotein hormones having altered...

Details Analogs of glycoprotein hormones having altered... Analogs of glycoprotein hormones having altered...

C - Chemistry, Metallurgy

07

K

C07K 14/59 (2006.01) C07K 14/145 (2006.01) C07K 14/575 (2006.01) C07K 16/26 (2006.01) C07K 19/00 (2006.01) C12N 15/85 (2006.01) C12N 15/89 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2082424

The invention relates to modified chorionic gonadotropin (CG) alpha, beta- heterodimeric polypeptides comprising a gly- coprotein hormone alpha-subunit polypeptide and a non-naturally occurring beta- subunit polypeptide. The modifications in the beta-subunit polypeptide involve tho deletion, addition, or substitution of one or more amino acid residues. The modified heter- odimeric polypeptides of the invention have different properties compared to native hCG. Certain alpha, beta-heterodimeric pol- ypeptides bind to LH and FSH receptors and stimulate steroidogenesis in testicular and ovarian cells. Other alpha, beta-heterodi- meric polypeptides bind to LH receptors but have lower efficacy than hCG to stimulate steroidogenesis in testicular and ovarian cells.

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