C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/18 (2006.01) A61K 38/18 (2006.01) C07K 14/50 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2201944
Analogs of proteins in the FGF family are provided in accordance with the present invention. These analogs are more stable than the corresponding naturally occurring proteins. Enhanced stability may be achieved by substituting at least one amino acid having a higher loop-forming potential for an amino acid residue having a lower loop-forming potential in an identified loop-forming region in the amino acid sequence of the protein. The analogs of the present invention are especially useful in therapeutic applications.
La présente invention permet d'obtenir des analogues des protéines de la famille des FGF. Ces analogues sont plus stables que les protéines naturelles correspondantes. Une stabilité accrue peut être obtenue en substituant au moins un acide aminé ayant un potentiel de formation de boucle plus élevée par un résidu d'acide aminé ayant un potentiel de formation de boucle plus faible dans une région identifiée de formation de boucle dans la séquence d'acides aminés de la protéine. Les analogues issus de la présente invention sont particulièrement utiles dans des applications thérapeutiques.
Arakawa Tsutomu
Fox Gary Michael
Amgen Inc.
Gowling Lafleur Henderson Llp
LandOfFree
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