C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/18 (2006.01) A61K 38/18 (2006.01) C07K 14/50 (2006.01) A61K 38/00 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)
Patent
CA 2202075
The present invention concerns polypeptide analogs of a potent mitogen of non- fibroblast epithelial cell growth, keratinocyte growth factor (KGF) having up to the first 24 N-terminal amino acids modified wherein cysteine residues corresponding to amino acid positions 1 and 15 of the KGF [amino acid positions 32 and 46 of SEQ ID No:2, (Cys1 and Cys15, respectively), are deleted or substituted with another amino acid. Also disclosed are nucleic acid molecules encoding such analogs, as well as methods for using such analogs to stimulate non-fibroblast epithelial cell proliferation.
L'invention concerne des polypeptides analogues d'un puissant mitogène de la croissance des cellules épithéliales non-fibroblastiques, le facteur de croissance des kératinocytes (FCK) ayant jusqu'aux 24 premiers acides aminés à terminaison N modifiés, où les résidus de cystéine correspondant aux positions des acides aminés 1 et 15 du FCK [positions des acides aminés 32 et 46 de la SEQ. ID No:2 (Cys<1> et Cys<15>, respectivement)] sont supprimés ou substitués par un autre acide aminé. L'invention concerne également des molécules d'acide nucléique de codage de ces analogues, ainsi que des procédés d'utilisation de ces analogues afin de stimuler la prolifération des cellules épithéliales non-fibroblastiques.
Chen Bao-Lu
Hsu Eric W.
Kenney William C.
Morris Charles F.
Amgen Inc.
Biovitrum Ab (publ)
Gowling Lafleur Henderson Llp
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