Analogs of parathyroid hormone

Details Analogs of parathyroid hormone Analogs of parathyroid hormone

C - Chemistry, Metallurgy

07

K

C07K 14/635 (2006.01) A61K 38/29 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2226177

Peptide variants of fragment (1-34) of parathyroid hormone, in which at least one of the amino acid residues at positions 7, 11, 23, 24, 27, 28 and 31 is cyclohexylalanine, or at least one of the amino acid residues at positions 3, 16, 17, 18, 19 and 34 is .alpha.-aminoisobutyric acid; or, alternatively, at least the amino acid residue at position 1 is .alpha.,.beta.-diaminopropionic acid, the amino acid residue at position 27 is homoarginine, or the amino acid residue at position 31 is norleucine.

L'invention concerne des variants peptidiques du fragment (1-34) de la parathormone qui comportent au moins un résidu cyclohexylalanine en position 7, 11, 23, 24, 27, 28 ou 31 ou au moins un résidu acide .alpha.-amino-isobutyrique en position 3, 16, 17, 18, 19 ou 34, ou, à tout le moins, un résidu acide .alpha.,.bêta.-diaminopropionique en position 1, un résidu homoarginine en position 27 ou un résidu norleucine en position 31.

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