Analogs of peptidase substrates

Details Analogs of peptidase substrates Analogs of peptidase substrates

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A61K 38/06 (2006.01) A61K 38/07 (2006.01) A61K 38/08 (2006.01) C07C 271/16 (2006.01) C07C 271/18 (2006.01) C07C 271/20 (2006.01) C07C 271/22 (2006.01) C07K 5/02 (2006.01) C07K 5/06 (2006.01) C07K 5/08 (2006.01) C07K 5/10 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2001265

This invention relates to novel analogs of certain peptidase substrates in which the nitrogen atom of the scissile amide bond has been replaced with a difluoromethylene moiety and in which the carbonyl moiety of its adjacent amide bond has been replaced with a terminal amine function, said novel analogs having the property of inhibiting renin and which are useful in the treatment of hypertension.

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