Analogs of piscine lhrh

Details Analogs of piscine lhrh Analogs of piscine lhrh

C - Chemistry, Metallurgy

12

N

C12N 15/16 (2006.01) A61K 38/09 (2006.01) A61K 38/10 (2006.01) A61K 39/00 (2006.01) A61K 39/385 (2006.01) A61K 39/395 (2006.01) C07K 7/23 (2006.01) C07K 16/26 (2006.01) C07K 16/42 (2006.01) G01N 33/566 (2006.01) G01N 33/74 (2006.01)

Patent

CA 2100057

2100057 9212247 PCTABS00014 An analog of piscine GnRH is disclosed having the amino acid sequence: pGlu-His-Trp-Ser-Tyr-W-Trp-Leu-Arg-Pro-Gly-X-Y-Z wherein W represents Gly or a D-amino acid, X represents a bond, or one or more amino acids which may be the same or different, Y represents Cys or Tyr or is absent, and Z is absent or represents one or more amino acids which may be the same or different or a continuous or discontinuous peptide chain, the or each discontinuity being a non-.alpha. amino acid polyfunctional linker moiety or a retro-inverso amino acid with the proviso that when W is Gly and X and Y are absent Z is present. The analog may be conjugated to a carrier and used, for example, to delay onset of sexual maturation and enhance growth.

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