Analogs of pth and pthrp, their synthesis and use for the...

Details Analogs of pth and pthrp, their synthesis and use for the... Analogs of pth and pthrp, their synthesis and use for the...

C - Chemistry, Metallurgy

07

K

C07K 14/635 (2006.01) A61K 38/29 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2140281

Synthetic polypeptide analogs of parathyroid hormone PTH, parathyroid hormone related peptide PTHrp, and of the phy- siologically active truncated homologs and analogs of PTH and PTHrp, in which amino acid residues (22-31) form an amphi- pathic .alpha.-helix, said residues (22-31) selected from hydrophilic amino acids (Haa) and lipophilic amino acids (Laa) ordered in the sequence: Haa(Laa Laa Haa Haa)2 Laa and their pharmaceutically acceptable salts are useful for the prophylaxis and treat- ment of osteoporosis in mammals. Processes for the production of the polypeptides via solid phase and recombinant meth- ods are provided.

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