Analogs of thymosin .alpha.1

Details Analogs of thymosin .alpha.1 Analogs of thymosin .alpha.1

C - Chemistry, Metallurgy

07

K

C07K 14/575 (2006.01) C07K 1/04 (2006.01) C07K 1/06 (2006.01) C07K 7/04 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2181477

Compounds of formula (I), wherein X is an acetyl or pyroglutamyl group and Z is -NH2, -Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-Pro-NH2, -Lys-Glu- Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-Gly-NH2, or -Lys-Glu-Lys-Lys-Glu-Val- Val-Glu-Glu-Ala-Glu-Asn with the proviso that when X is a pyroglutamyl group, Z is -Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn, and when X is an acetyl group, Z is other than -Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn and methods for the production thereof.

Cette invention se rapporte à des composés représentés par la formule (I), où X représente un groupe acétyle ou pyroglutamyle et Z représente NH¿2?, -Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-Pro-NH¿2?, -Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-Gly-NH¿2? ou -Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn, à condition que, lorsque X représente un groupe pyroglutamyle, alors Z représente -Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn, et, lorsque X représente un groupe acétyle, alors Z est autre que -Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn, ainsi qu'à des procédés pour produire de tels composés.

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