C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/47 (2006.01) A61K 38/04 (2006.01) A61K 38/17 (2006.01) A61P 19/00 (2006.01) A61P 31/00 (2006.01) C07K 7/08 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2308036
The invention provides an LPS-binding and -neutralizing peptide comprising the amino acid sequence X-1-2-3-4-5-6-7-8-9-10-11-12-13-14-Y, wherein: X is a linear chain from zero to four amino acids. (1) is one of the amino acids alanine, threonine, glutamine, asparagine or serine; and if and only if at least one of the a.a. at positions +5, +9, +10, +11 or +13 has been replaced (from the native LBP sequence) according to what is herein described, then (1) could also be arginine or lysine. (2) is one of the amino acids alanine, valine, isoleucine, leucine, phenylalanine, methionine, tryptophan or tyrosine. (3) is one of the amino acids glutamine, asparagine, serine or threonine. (4) is one of the amino acids glycine, alanine, valine, isoleucine, leucine, phenylalanine, methionine, tryptophan or tyrosine. (5) is one of the amino acids alanine, threonine, glutamine, asparagine or serine; and if and only if at least one of the a.a. at positions +1, t9, t10, +11 or +13 has been replaced according to what is herein described, then (5) could also be arginine or lysine. (6) is one of the amino acids tryptophan or phenylalanine. (7) is one of the amino acids lysine or arginine. (8) is one of the amino acids alanine, valine, isoleucine, leucine, phenylalanine or tyrosine. (9) is one of the amino acids alanine, threonine, glutamine, asparagine or serine; and if and only if at least one of the a.a. at positions +1, +5, +10, +11 or +13 has been replaced according to what is herein described, then (9) could also be arginine or lysine. (10) is one of the amino acids alanine, valine, isoleucine, leucine, phenylalanine, methionine, tryptophan or tyrosine; and if and only if at least one of the a.a. at positions +1, +5, +g, +11 6 +13 has been replaced according to what is herein described, then (10) could also be lysine or arginine. (11) is one of the amino acids alanine or valine; and if and only if at least one of the a.a. at positions +1, +5, +g, +10, o +13 has been replaced according to what is herein described, then (11) could also be serine; and if and only if the a.a. at position +10 has bean replaced according to what is herein described, then (11) could also be threonine, glutamine, asparagine, lysine or arginine. (12) is one of the amino acids phenylalanine, tryptophan or tyrosine. (13) is one of the amino acids alanine, threonine, glutamine, asparagine or serine; and if and only if at least one of the a.a. at positions +1, +5, +9, +10 o +11 has been replaced according to what is herein described, then (13) could also be phenylalanine, arginine or lysine; and if and only if the a.a at position +14 is lysine or arginine, then (13) could also be glycine. (14) is one of the amino acids lysine, arginine or alanine, and if and only if the a.a. at position t13 has been replaced according to what is herein described, then (14) could also be valine, isoleucine, leucine, phenylalanine, methionine, tryptophan or tyrosine.
Arana Rosainz Manuel de Jesus
Glay Chinea Santiago
Guerra Vallespi Maribel
Reyes Acosta Osvaldo
Borden Ladner Gervais Llp
Centro de Ingenieria Genetica Y. Biotecnologia
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