Analogues of neuropeptide y having at least one synthetic...

Details Analogues of neuropeptide y having at least one synthetic... Analogues of neuropeptide y having at least one synthetic...

C - Chemistry, Metallurgy

07

K

C07K 14/575 (2006.01) A61K 38/17 (2006.01)

Patent

CA 2751636

The present invention relates to novel analogues of neuropeptide Y, pharmaceutical compositions containing the same, pharmaceutical formulations containing the same, and method of treating diseases or conditions mediated by neuropeptide Y-receptor binding. More particularly, the present invention relates to novel analogues of neuropeptide Y having at least one unnatural amino acid substitution, such as 4Hyp at position 34, that selectively bind to the neuropeptide Y1 receptor subtype compared to the neuropeptide Y2 receptor subtype.

La présente invention porte sur de nouveaux analogues de neuropeptide Y, sur des compositions pharmaceutiques les contenant, sur des formulations pharmaceutiques les contenant et sur un procédé de traitement de maladies ou d'états à médiation par une liaison au récepteur du neuropeptide Y. Plus particulièrement, la présente invention porte sur de nouveaux analogues de neuropeptide Y ayant au moins une substitution par acide aminé non naturel, telle que 4Hyp en position 34, qui se lient sélectivement au sous-type du récepteur de neuropeptide Y1 par comparaison au sous-type du récepteur de neuropeptide Y2.

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