C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/57 (2006.01) C07K 14/705 (2006.01) C12N 15/10 (2006.01) C12N 15/12 (2006.01) C12P 19/34 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2522815
The invention relates to polynucleotide sequences comprising genetic variations of PAR 1 gene on positions 3090 and/or 3329. Surprisingly, the presence of said variants in humans correlates with specific cardiovascular diseases. The invention also relates to methods for the detection of said genetic variations.
L'invention concerne des séquences polynucléotidiques comprenant des variations génétiques du gène PAR 1 au niveau des positions 3090 et/ou 3329. Très étonnamment, l'occurrence de ces variantes chez l'homme est en corrélation avec certaines maladies cardiovasculaires. Cette invention se rapporte en outre à des procédés pour identifier ces variations génétiques.
Czech Joerg
Deleuze Jean-Francois
Kozian Detlef
Mace Sandrine
Ricard Sylvain
Aventis Pharma Deutschland Gmbh
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Sanofi-Aventis Deutschland Gmbh
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