C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/02 (2006.01) B01D 61/18 (2006.01) B01D 67/00 (2006.01) B01D 71/02 (2006.01) B01J 19/00 (2006.01) B01L 3/00 (2006.01) B01L 7/00 (2006.01) C12M 1/26 (2006.01) C12M 1/34 (2006.01) C12M 3/00 (2006.01) C12M 3/08 (2006.01) C12Q 1/68 (2006.01) G01N 33/543 (2006.01) G01N 33/569 (2006.01) A61B 17/04 (2006.01) B01F 5/06 (2006.01)
Patent
CA 2134477
Disclosed are devices and methods for detecting the presence of a preselected analyte in a fluid sample. The invention provides a device comprising a solid substrate, typically on the order of a few millimeters thick and approximately a 0.2 to 2.0 centimeters square, microfabricated to define a sample inlet port (16A) and a mesoscale flow system. A sample is passed through the mesoscale flow system, and the restriction or blockage of flow through the flow system is detected as a positive indication of the presence of the analyte. The mesoscale flow system includes in one embodiment a primary sample flow channel (20) extending from the inlet port (16A); and a fractal region (40), in fluid communication with the flow channel (20), comprising bifurcations leading to plural secondary flow channels. Means may be provided in the device for inducing flow of a sample through the flow system. Means also may be provided for detecting analyte induced changes, in flow properties in the mesoscale flow system. The devices of the invention may be used in a wide range of applications, including the detection of cells or macromolecules, such as viruses.
Kricka Larry J.
Wilding Peter
Borden Ladner Gervais Llp
The Trustees Of The University Of Pennsylvania
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