Analysis of antibody drug conjugates by bead-based affinity...

Details Analysis of antibody drug conjugates by bead-based affinity... Analysis of antibody drug conjugates by bead-based affinity...

G - Physics

01

N

G01N 33/50 (2006.01)

Patent

CA 2720124

Methods to detect, characterize, and quantitate biological samples after administration of antibody conjugates, antibody-drug conjugates of Formula I, antibodies, and fragments and metabolites thereof, by immunoaffinity bead separation, chromatography, and mass spectrometry are disclosed. Ab-(L-D)p wherein Ab is an antibody; D is a drug moiety; L is a linker covalently attached to Ab, and covalently attached to D; and p is 1, 2, 3, 4, 5, 6, 7, or 8.

L'invention porte sur des procédés pour détecter, caractériser et quantifier des échantillons biologiques après administration de conjugués d'anticorps, de conjugués anticorps-médicament de Formule I, d'anticorps et de fragments et de métabolites de ceux-ci, par séparation de bille par immunoaffinité, chromatographie et spectrométrie de masse. Ab-(L-D)p, formule dans laquelle Ab est un anticorps; D est une fraction de médicament; L est un liant lié de façon covalente à Ab, et lié de façon covalente à D; et p est 1, 2, 3, 4, 5, 6, 7 ou 8.

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