Analysis of dna

Details Analysis of dna Analysis of dna

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C07H 21/04 (2006.01)

Patent

CA 2252030

A novel highly polymorphic DNA marker based on the pentanucleotide repeat (CCTTT/GGAAA)n has been identified in the human inducible nitric oxide synthase (iNOS) gene. Twelve different alleles, having between 7 and 18 contiguous repeats, have been identified. The repeat is highly polymorphic in the human population and so lends itself to use as a microsatellite marker with uses in, for example, forensic medicine, population studies, family linkage studies and disease diagnosis.

Un nouveau marqueur d'ADN très polymorphe, basé sur la répétition de pentanucléotides (CCTTT/GGAAA), a été identifié dans le gène inductible chez l'homme de la monoxyde d'azote synthétase (iNOS). Douze allèles différents, comportant 7 à 18 répétitions contiguës, ont été identifiés. La répétition est très polymorphe dans la population humaine et se prête donc à une utilisation en tant marqueur microsatellite, par exemple pour la médecine légale, les études de population, les études de liens familiaux et le diagnostic de certaines maladies.

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