Analysis of glycated proteins

Details Analysis of glycated proteins Analysis of glycated proteins

G - Physics

01

N

G01N 33/68 (2006.01)

Patent

CA 2731884

This invention relates to a method for analysis of one or more glycated proteins in a sample, the glycated proteins containing moieties of a natural reducing carbohydrate bound at one or more glycation sites in the proteins, the method comprising: treating the sample with a stable isotopic form of said carbohydrate which is different in mass from the natural carbohydrate, whereby the isotopic form becomes incorporated by glycation in one or more proteins in the sample, and one or more of said proteins are accordingly glycated by the natural reducing carbohydrate and by the isotopic form of the carbohydrate at identical glycation sites; and identifying and/or quantifying the glycated proteins by the difference in mass between the natural carbohydrate and the isotopic form of the carbohydrate at identical glycation sites.

Linvention concerne un procédé danalyse dune ou de plusieurs protéines glycatées dans un échantillon, les protéines glycatées contenant des fractions dun glucide réducteur naturel lié à un ou à plusieurs sites de glycation des protéines. Le procédé comprend les étapes consistant à : traiter léchantillon à laide dune forme isotopique stable du glucide, qui présente une masse différente de celle du glucide naturel, la forme isotopique sintégrant par glycation dans une ou plusieurs protéines de léchantillon, et une ou plusieurs desdites protéines étant ainsi glycatée(s) par le glucide réducteur naturel et par la forme isotopique du glucide à des sites de glycation identiques; et identifier et/ou quantifier les protéines glycatées par la différence de masse entre le glucide naturel et la forme isotopique du glucide à des sites de glycation identiques.

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