Analysis of mixtures including proteins

Details Analysis of mixtures including proteins Analysis of mixtures including proteins

G - Physics

01

N

G01N 21/33 (2006.01) A61K 39/095 (2006.01) G01J 3/42 (2006.01) G01J 3/433 (2006.01) G01J 3/44 (2006.01) G01N 21/64 (2006.01)

Patent

CA 2708585

The quality control of vaccines is an important step in the release of vaccines to patients. Problems when dealing with vaccines include stability, batch-to-batch consistency and contamination. The invention provides a method of analyzing the composition of a protein-containing sample by electromagnetic spectroscopy, and derivatising the obtained spectrum to obtain a derivative spectrum of the sample. The derivative spectrum may optionally be compared to a reference spectrum, to assess stability, contamination etc. relative to the reference. The derivative analysis technique allows the separation and discrimination between the spectral contributions of different components, thereby allowing differences in the spectra to be assigned to particular groups of the protein, or particular contaminants etc.

Le contrôle de la qualité de vaccins constitue une étape importante dans l'administration de vaccins aux patients. Des problèmes rencontrés lors de la manipulation de vaccins comprennent la stabilité, l'uniformité d'un lot à l'autre et la contamination. L'invention concerne un procédé d'analyse de la composition d'un échantillon contenant des protéines par spectroscopie électromagnétique et de dérivatisation du spectre obtenu pour obtenir un spectre dérivé de l'échantillon. Le spectre dérivé peut éventuellement être comparé à un spectre de référence, pour évaluer la stabilité, la contamination, etc. par rapport à la référence. La technique d'analyse du dérivé permet la séparation et la discrimination entre les contributions spectrales de différents composants, permettant ainsi d'assigner des différences dans le spectre à des groupes particuliers de la protéine ou à des contaminants particuliers, etc.

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