Analytical element containing a barrier zone and process...

G - Physics – 01 – N

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150/11, 150/3

G01N 33/49 (2006.01) C08J 5/18 (2006.01) G01N 33/52 (2006.01)

Patent

CA 1189429

Abstract of the Disclosure Disclosed herein is a multizone element, for quantitative analyte determination in whole blood, containing a porous spreading zone separated from a reagent zone by a barrier zone, said barrier zone comprising a non-porous film comprising a polymer of: from 30 to 95 percent by weight of polymerized mono- mer having the structure Image from 0.25 to 30 percent by weight of polymerized monomer having the structure Image , and from 0.1 to 50 percent by weight of polymerized monomer having the structure Image wherein: R1, R3, and R5 are independently selected from the group consisting of hydrogen and methyl, R2 is alkyl of from 1 to 16 carbon atoms, R4 and R6 are independently selected from the group consisting of alkylene groups having from 1 to 6 carbon atoms, Image wherein R7 is hydrogen, alkyl of 1 to 10 carbon atoms, or cycloalkyl of 5 to 10 carbon atoms, and M is NR?R9H+X or SO,-X wherein R? and R9 are independently selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms and X is n counterion. A process for employing the element in analyses for analytes in whole blood is also dis- closed.

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