Analytical test article and method

Details Analytical test article and method Analytical test article and method

G - Physics

01

N

150/9, 73/51.5

G01N 21/00 (2006.01)

Patent

CA 1094931

ABSTRACT OF THE DISCLOSURE A body suitable for use in the quantitative detection of an unknown quantity of a biologically derived sample suitably by radioimmunoassay, fluoro- metric detection, or by spectrophotometry. The body includes a handle attached to a nonparticulate, nonswellable, impermeable continuous surface region. A diagnostic reagent (e.g., an antibody) is covalently attached to the surface region. The surface region is stirred by the handle in a solution of sample substance (e.g., antigen) for reaction with the diagnostic reagent. In a competitive binding technique, a labelled substance (e.g., fluorochrome labelled antigen) is simultaneously contacted with the sample. Thereafter, the surface region is washed, and the label is measured as by a fluorometer. The technique is also applicable to the so-called "sandwich technique" in which the labelled substance (e.g., labelled antibody) is reacted with the sample substance after it has been reacted with the diagnostic reagent. The above type of surface facilitates simple and effective separation of bound from free labelled sub- stance and allows thorough washing to cleanse the surface of residual free and non-specifically bound labelled substance.

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