G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 35/10 (2006.01) G01B 7/02 (2006.01) G01N 35/04 (2006.01)
Patent
CA 2147738
An analyzer comprising the following components: a horizontally disposed baseplate (12) on which primary containers (13 and 23) and secondary containers (31) are disposed; a pipetting needle (42) consisting of an electrically conductive material and connected to a metering device (96) by a tubing (99), for transferring a predetermined volume of liquid each time from a primary container (13 and 23) to a secondary container (31); a transport device (51 - 55) for the controlled transport of the pipetting needle (42) in three directions at right angles to one another (the X, Y and Z directions), two of the transport directions (X and Y directions) extending horizontally and the third transport direction (Z direction) extending vertically; an electrically conductive reference body (45) which is rigidly connected to baseplate (12) and which in each of the horizontal transport directions (X and Y directions) has two outer surfaces (76, 77; 78, 79) which are disposed perpendicularly to the transport direction; and a control device for controlling the metering device (96) and the transport device. For fine adjustment of the transport device (51 - 55) of the pipetting needle (42) the analyzer further comprises: a circuit for measuring the electrical capacitance between the pipetting needle (42) and the reference body (45), and means for determining the coordinates of a reference position of the pipetting needle (42) in at least one of the horizontal transport directions (X and Y directions), said means being adapted to so move the transport device (51 - 55) of the pipetting needle (42) that the pipetting needle (42) is moved in opposite directions in each case to a position near each of the two outer surfaces (76, 77; 78, 79) of the reference body (45) which are disposed perpendicularly to the transport direction, the pipetting needle (42) being moved in each case towards a surface of the reference body (45) until the value of the electrical capacitance between the pipetting needle (42) and the reference body (45) as measured by the circuit reaches a predetermined value corresponding to a specific distance between the pipetting needle (42) and the surface of the reference body (45).
Bonacina Guido Richard
Caratsch Thomas Martin
Moser Rolf Xaver
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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