C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
167/129, 167/37
C12P 21/00 (2006.01) A61K 39/02 (2006.01) C07K 14/29 (2006.01) C07K 16/12 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)
Patent
CA 1272124
Abstract of the Disclosure Substantially pure antigenic surface proteins of Anaplasma marginale have been identified, and are capable of inducing immune responses in ruminants which neutralizes virulent Anaplasma marginale. The antigenic surface proteins have one or more components having a molecular weight of about 105,000 daltons, 86,000 daltons, 61,000 daltons, 36,000 daltons, 31,000 daltons, or 15,000 daltons, and can be purified by an immunoaffinity chromotography process comprising the steps of disrupting Anaplasma marginal initial bodies by treatment with a detergent, passing the disrupted initial bodies over a chromotogrnphy column comprising an insoluble matrix coupled to monoclonal antibodies against a determinant on said antigenic surface protein to selectively bind said antigenic surface protein to said monoclonal antibodies and recovering the bound substantially pure antigenic surface protein from said insoluble matrix. The antigens have further utility in diagnostic tests for anaplasmosis. They can be synthesized by polypeptide procedures or by genetic engineering.
504925
Barbet Anthony F.
Davis William C.
Mcguire Travis C.
Palmer Guy H.
Barbet Anthony F.
Davis William C.
Gowling Lafleur Henderson Llp
Mcguire Travis C.
Palmer Guy H.
LandOfFree
Anaplasma marginale subunit antigen for vaccination and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Anaplasma marginale subunit antigen for vaccination and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anaplasma marginale subunit antigen for vaccination and... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1285336