Anaplastic lymphoma kinase modulators and methods of use

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 277/20 (2006.01)

Patent

CA 2559866

The present invention relates to compounds of the Formula I, wherein L, X, Y, Z, R1, R2, R3 and R4 are defined herein. The invention also provides methods of using the compounds for inhibition of kinases, more specifically ALK kinases. The invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinase receptor signal transduction pathways related to the changes in cellular activities as mentioned above, and the invention includes compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions; (Formula I).

L'invention concerne des composés de formule I, dans laquelle L, X, Y, Z, R?1¿, R?2¿, R?3¿ et R?4¿ sont tels que définis dans la description. L'invention concerne également des méthodes d'utilisation de ces composés pour inhiber des kinases, plus particulièrement des kinases ALK. L'invention porte sur des composés destinés à moduler l'activité enzymatique de protéines kinases pour moduler des activités cellulaires telles que la prolifération, la différenciation, la mort cellulaire programmée, la migration et la chimio-invasion. Les composés selon l'invention inhibent, régulent et/ou modulent les voies de transduction du signal des récepteurs de kinases, ces voies étant liées aux changements au niveau des activités cellulaires susmentionnées. L'invention concerne enfin des compositions contenant lesdits composés, ainsi que des méthodes d'utilisation de ces composés pour traiter des maladies et des états dépendant des kinases.

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