Ancestral dengue virus envelope protein sequence

Details Ancestral dengue virus envelope protein sequence Ancestral dengue virus envelope protein sequence

A - Human Necessities

61

K

A61K 39/12 (2006.01)

Patent

CA 2622739

Disclosed is a dengue virus envelope protein sequence derived via ascertainment of a most recent common ancestor of the three dengue serotype variants, DENV-I, DENV-2, DENV-3 and DENV-4. This synthetic dengue virus envelope protein can be used as a tetravalent vaccine in the preventinon of dengue fever, dengue hemorrhagic fever and dengue septic shock.

L'invention concerne une séquence protéique de l'enveloppe du virus de la dengue dérivée par vérification d'un ancêtre commun le plus récent des trois variants des sérotypes de la dengue : DENV-I, DENV-2, DENV-3 et DENV-4. Cette protéine de l'enveloppe du virus de la dengue synthétique peut être utilisé comme vaccin tétravalent dans la prévention de la dengue, de la dengue hémorragique et du choc septique de la dengue.

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