Androgen receptor-ablative agents

Details Androgen receptor-ablative agents Androgen receptor-ablative agents

C - Chemistry, Metallurgy

07

D

C07D 277/34 (2006.01) A61K 31/426 (2006.01) A61K 31/427 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2716047

Compounds of the thiazolidinedione family are provided and shown to be effective androgen receptor ablative agents that can be used in methods of treating or preventing cancer or precancer, including prostate cancer. Also provided are methods of treating or preventing cancer by administering a therapeutically effective amount of one of the androgen receptor ablative agents to a subject in need of such treatment.

L'invention porte sur des composés de la famille des thiazolidinedione s'étant montré d'efficaces agents ablatifs du récepteur androgène, pouvant servir dans des méthodes de traitement ou prévention de cancers ou de précancers dont celui de la prostate. L'invention porte également sur des méthodes de traitement ou prévention de cancers par administration de doses à efficacité thérapeutique d'un desdits agents à un patient le nécessitant.

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