Androgen receptor antagonists

Details Androgen receptor antagonists Androgen receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 405/12 (2006.01) A61K 31/4035 (2006.01) A61K 31/453 (2006.01) A61K 31/454 (2006.01) A61K 31/4709 (2006.01) A61K 31/4725 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) A61K 31/55 (2006.01) A61K 31/5513 (2006.01) A61P 5/28 (2006.01) C07D 215/227 (2006.01) C07D 311/54 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 491/048 (2006.01) C07D 491/08 (2006.01) C07D 491/10 (2006.01) C0

Patent

CA 2511491

The present invention is directed to a new class of 6-sulfonamido-quinolin-2- one and 6~-sulfonamido-2-oxo-chromene derivatives to their use as androgen antagonists, and to relieve conditions associated with inappropriate activation of the androgen receptor. These compounds may be represented by the formula (I), in which; M is NZ or O; A is represented by -S(62): %3.

La présente invention concerne une nouvelle classe de dérivés de 6-sulfonamido-quinolin-2-one et de 6-sulfonamido-2-oxo-chromène, et leur utilisation en tant qu'antagonistes d'androgènes, qui permet de soulager les états associés à une activation inappropriée de récepteurs d'androgènes.

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