C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 498/04 (2006.01) A61K 31/502 (2006.01) A61K 31/538 (2006.01) A61K 31/5415 (2006.01) A61P 5/26 (2006.01) A61P 5/28 (2006.01) C07D 209/00 (2006.01) C07D 221/00 (2006.01) C07D 241/00 (2006.01) C07D 265/00 (2006.01) C07D 279/00 (2006.01) C07D 471/04 (2006.01) C07D 513/04 (2006.01)
Patent
CA 2383077
Compounds, pharmaceutical compositions, and methods for modulating processes mediated by steroid receptors. In particular, preparation and methods of use of non-steroidal compounds and compositions that are agonists, partial agonists, and antagonists for the androgen receptor (AR) are described. Further, described are the methods of making and use of critical intermediates including a stereoselective synthetic route to intermediates for the AR modulators.
L'invention concerne des composés, des compositions pharmaceutiques, et des procédés permettant de moduler des processus induits par des récepteurs stéroïdiens. L'invention concerne notamment la préparation et des procédés d'utilisation de compositions et de composés non stéroïdiens étant des agonistes, des agonistes partiels et des antagonistes du récepteur androgène. L'invention concerne en outre des procédés de préparation et d'utilisation d'intermédiaires critiques comprenant une voie synthétique stéréosélective vers des intermédiaires des modulateurs du récepteur androgène.
Arienti Kristen L.
Caferro Thomas R.
Chen Penghui
Higuchi Robert
Mani Neelakandha S.
Ligand Pharmaceuticals Incorporated
Smart & Biggar
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