A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01) A61K 48/00 (2006.01) C07K 14/00 (2006.01) C07K 14/47 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/543 (2006.01)
Patent
CA 2485138
This invention relates to an androgen-regulated gene, PMEPA1, and proteins encoded by this gene, including variants and analogs thereof. Methods of inhibiting cancer cell growth, reducing androgen receptor expression, modulating the expression of genes that are transcriptionally regulated by androgen receptor, and diagnosing and/or prognosing prostate cancer are also provided.
La présente invention concerne un gène régulé par les androgènes, PMEPA1, et des protéines codées par ce gène, y compris des variants et des analogues de ces dernières. L'invention se rapporte également à des procédés permettant d'inhiber la croissance de cellules cancéreuses, de réduire l'expression du récepteur des androgènes, de moduler l'expression de gènes qui sont régulés transcriptionnellement par le récepteur des androgènes, et de diagnostiquer et/ou pronostiquer le cancer de la prostate.
Moul Judd W.
Srivastava Shiv
Xu Linda L.
Henry M. Jackson Foundation For The Advancement Of Military Medi
Kirby Eades Gale Baker
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